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Updated: Jul 6, 2025
08:20
Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
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[Research progress in associations between dental caries and systemic diseases]
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
Summary
Dental caries, a chronic progressive disease, is linked to various systemic conditions. This review explores the connections between oral health and overall health, offering insights for better prevention and treatment.
Area of Science:
- Oral Health and Systemic Medicine
- Microbiology and Immunology
- Chronic Disease Epidemiology
Background:
- Dental caries is a complex, multifactorial disease involving demineralization and remineralization of dental tissues.
- Emerging research highlights significant associations between dental caries and various systemic diseases.
- Understanding these links is crucial for comprehensive patient care.
Approach:
- A systematic literature review was performed using PubMed and Web of Science databases.
- Articles published between 2003 and 2022 were analyzed for associations between dental caries and systemic conditions.
- Ten categories of systemic diseases were investigated, including cardiovascular, metabolic, autoimmune, and neoplastic diseases.
Key Points:
- Dental caries is associated with cardiovascular diseases, metabolic disorders, and respiratory conditions.
- Links were observed between caries and autoimmune rheumatic, neurologic, and gastrointestinal diseases.
- The review also covers associations with kidney diseases, skin conditions, iron deficiency anemia, and tumors.
Conclusions:
- Dental caries is intricately connected with a wide spectrum of systemic diseases.
- Exploring these relationships offers novel strategies for disease prevention and management.
- Interdisciplinary approaches involving dentists and clinicians are vital for integrated healthcare.
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