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Glutamine addiction in tumor cell: oncogene regulation and clinical treatment

Xian Li1, Xueqiang Peng1, Yan Li1

  • 1Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China.

Cell Communication and Signaling : CCS
|January 4, 2024
PubMed

Insights

Targeting cancer cell glutamine metabolism is a promising strategy. This review details glutamine

Area of Science:

  • Oncology
  • Cancer Metabolism
  • Biochemistry

Background:

  • Tumor cells reprogram metabolism, increasing glutamine consumption for proliferation.
  • Glutamine metabolism is crucial for cancer cell survival and progression.

Purpose of the Study:

  • To review glutamine metabolism in tumor cells.
  • To explore its role in biosynthesis and cancer development.
  • To assess anti-cancer agents targeting glutamine metabolism.

Main Methods:

  • Literature review of glutamine metabolism in cancer.
  • Summary of oncogene regulation (C-MYC, KRAS, HIF, p53) on glutamine metabolism.
  • Analysis of glutamine's role in mTORC1 activation.

Main Results:

  • Glutamine fuels biosynthesis of amino acids, nucleotides, and fatty acids.
  • Oncogenes significantly regulate glutamine metabolism.
  • Glutamine activates mTORC1 signaling pathway.

Conclusions:

  • Targeting glutamine metabolism offers a viable anti-cancer strategy.
  • Understanding glutamine's role is key for developing new cancer therapies.
Keywords:
GlutamineMetabolismOncogene clinical treatmentTumor

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