Association between triglyceride glucose index and all-cause mortality in patients with cerebrovascular disease: a
Yong'An Jiang1,2, Peng Chen1,2, YangYang Zhao1,2
1Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, P. R. China.
Insights
The triglyceride glucose (TyG) index is linked to increased short-term mortality in patients with cerebrovascular disease (CVD). Higher TyG levels predict a greater risk of death within 90 days for CVD patients, especially those with diabetes.
Area of Science:
- Cardiology
- Neurology
- Metabolic Syndrome
Background:
- The triglyceride glucose (TyG) index is an emerging biomarker associated with cardiovascular events like stroke and atherosclerosis.
- While linked to adverse outcomes, its specific impact on cerebrovascular disease (CVD) mortality requires further investigation.
Purpose of the Study:
- To investigate the association between the TyG index and short-term mortality (28-day and 90-day) in patients diagnosed with cerebrovascular disease (CVD).
Main Methods:
- Utilized data from the Medical Information Mart for Intensive Care -IV database, categorizing 1,965 patients into TyG index quartiles.
- Employed Kaplan-Meier survival analysis and Cox proportional risk modeling to assess survival disparities and the association between TyG index and mortality.
- Applied generalized summation models and log-likelihood ratio tests to analyze non-linear relationships.
Main Results:
- The TyG index showed a positive linear relationship with both 28-day (HR 1.16) and 90-day (HR 1.18) mortality in CVD patients.
- Patients in the highest TyG quartile (Q4) faced significantly elevated mortality risks, with each 1 mg/dL increase associated with a 35% rise in 28-day and 38% rise in 90-day mortality.
- The association between TyG index and 90-day mortality was more pronounced in the subgroup of patients with diabetes.
Conclusions:
- The TyG index is positively associated with 28-day and 90-day mortality in patients with cerebrovascular disease.
- This finding can aid in identifying high-risk CVD populations and improving clinical risk stratification and management.
Background:
Triglyceride glucose (TyG) is associated with stroke, atherosclerosis, and adverse clinical outcomes. However, its correlation with cerebrovascular disease (CVD) mortality remains unclear. This study aimed to investigate the relationship between TyG index and mortality in patients with CVD.
Methods:
Patient data sourced from the Medical Information Mart for Intensive Care -IV database were categorized based on TyG quartiles. Kaplan-Meier survival analysis was used to estimate survival disparities among the TyG subgroups. Cox proportional risk modeling was used to examine the association between the TyG index and mortality. Generalized summation models were applied to fit the smoothed curves. log-likelihood ratio test were used to analyze the non-linear relationship.
Results:
The study comprised 1,965 patients (50.18% were male). The 28-day and 90-day mortality rates were 20.10% and 24.48%, respectively. The TyG index exhibited a linear relationship with the 28-day mortality (Hazards ratio (HR), 1.16; 95% confidence interval (CI), 0.99-1.36) and the 90-day mortality (HR, 1.18; 95% CI, 1.02-1.37). In the TyG Q4 group, each 1 mg/dl increase was linked to a 35% rise in the risk of 28-day mortality and a 38% increase in the risk of 90-day mortality. Subgroup analyses highlighted a more substantial association between TyG index and 90-day mortality in the diabetic group.
Conclusion:
Our findings underscore the positive association between TyG and the 28- and 90-day mortality rates in patients with CVD. This insight may prove pivotal for identifying at-risk populations and enhancing risk prediction in the clinical management of CVD.
