Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

294
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
294

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bilayer PAM-PVA cartilage-inspired hydrogels with layer-selective CNT and nanodiamond interfacial reinforcement for structure-property control.

Nanoscale·2026
Same author

Advancements in Retinitis Pigmentosa: The Path Toward Personalized Treatment and Vision Restoration.

Current genomics·2026
Same author

Antimicrobial assessment and scanning electron microscopy analysis of sesquiterpene lactones isolated from the leaves of Inula racemosa Hook. f.

Archives of microbiology·2026
Same author

Effect of intraoperative events on quality of life in patients following clipping of ruptured anterior circulation aneurysms.

Surgical neurology international·2026
Same author

Exploring Quantum Dots for Diagnosis and Treatment of CNS Disorders: Toxicity, Biodistribution, and Emerging Challenges.

Current pharmaceutical design·2026
Same author

Modern plant stress adaptation: integrating defense, nanotechnology and genetics.

3 Biotech·2026

Related Experiment Video

Updated: Jul 6, 2025

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

65.3K

Poly(lactic-co-glycolic) Acid (PLGA) Nanoparticles and Transdermal Drug Delivery: An Overview.

Lalit Kumar1, Gauree Kukreti2, Ritesh Rana3

  • 1Department of Pharmaceutics, GNA School of Pharmacy, GNA University, Phagwara, Punjab 144401, India.

Current Pharmaceutical Design
|January 4, 2024
PubMed
Summary

Poly(lactic-co-glycolic acid) [PLGA] nanoparticles show promise for transdermal drug delivery, offering advantages over traditional methods. Further clinical research is needed to overcome challenges in their application.

Keywords:
BiodegradablePLGAdosage frequencynanoparticlespreclinicaltransdermal.

More Related Videos

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

37.4K
Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles
05:55

Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles

Published on: September 18, 2018

8.8K

Related Experiment Videos

Last Updated: Jul 6, 2025

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

65.3K
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

37.4K
Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles
05:55

Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles

Published on: September 18, 2018

8.8K

Area of Science:

  • Pharmaceutical Nanotechnology
  • Biomaterials Science

Background:

  • Biodegradable polymers, particularly Poly(lactic-co-glycolic acid) [PLGA], are increasingly important in the pharmaceutical industry for nanoparticle formulation.
  • PLGA's versatility supports nanoparticle preparation for diverse administration routes, including intravenous and transdermal.
  • Nanoparticle-based drug delivery systems are a key focus for enhancing therapeutic efficacy and patient compliance.

Approach:

  • This review systematically surveyed literature from databases like PubMed, Google Scholar, and Science Direct.
  • The focus was on methods for preparing and characterizing PLGA nanoparticles.
  • The review specifically examined the application of PLGA nanoparticles in transdermal drug delivery systems.

Key Points:

  • PLGA nanoparticles exhibit significant advantages in preclinical transdermal delivery compared to conventional systems.
  • Observed benefits include reduced side effects, less frequent dosing, enhanced skin penetration, and ease of use.
  • These nanoparticles function as effective nanocarriers for various therapeutic agents via the transdermal route.

Conclusions:

  • PLGA nanoparticles represent a promising platform for transdermal drug delivery.
  • Despite preclinical success, significant hurdles remain for the clinical translation of PLGA nanoparticles in transdermal therapy.
  • Continued research is essential to fully realize the potential of PLGA nanoparticles in clinical transdermal drug delivery.