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[Association Between Plasma Homocysteine Level and Hyperuricemia in Elderly Patients With Hypertension]

Ling-Juan Zhu1,2,3, Jian-Min Shi4, Tao Wang1,2,3

  • 1Cardiovascular Disease Prevention Center,The Second Affiliated Hospital of Nanchang University,Nanchang 330006,China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|January 4, 2024
PubMed

Insights

Elevated plasma homocysteine (Hcy) levels are significantly associated with an increased risk of hyperuricemia (HUA) in elderly hypertensive patients. Controlling Hcy levels may help prevent HUA in this population.

Area of Science:

  • Geriatric Medicine
  • Cardiovascular Research
  • Clinical Biochemistry

Context:

  • Hypertension is a prevalent condition in the elderly population.
  • Hyperuricemia (HUA) is a metabolic disorder associated with cardiovascular risks.
  • Plasma homocysteine (Hcy) is an emerging risk factor for various diseases.

Purpose:

  • To investigate the association between plasma homocysteine levels and hyperuricemia in elderly hypertensive patients.
  • To determine if elevated homocysteine is a risk factor for developing hyperuricemia in this demographic.

Summary:

  • A study of 9902 elderly hypertensive patients revealed a strong correlation between high plasma homocysteine (Hcy) levels and hyperuricemia (HUA).
  • Patients with hyperhomocysteinemia exhibited a significantly higher incidence and elevated levels of Hcy compared to those with normal uric acid levels.
  • Multivariate analysis indicated that hyperhomocysteinemia increases the risk of HUA by 2.92 times in elderly hypertensive individuals. A positive correlation was observed between Hcy levels and HUA risk up to 20 μmol/L.

Impact:

  • Findings suggest that monitoring and managing homocysteine levels could be a crucial strategy for preventing hyperuricemia in elderly hypertensive patients.
  • This research highlights a potential therapeutic target for reducing cardiovascular and metabolic complications in aging populations with hypertension.
  • Emphasizes the importance of considering homocysteine as a biomarker for hyperuricemia risk assessment in geriatric hypertension care.

Keywords:
homocysteinehypertensionhyperuricemiathreshold saturation effect

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