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Published on: February 10, 2023
Correlation between bradykinin concentration and blood pressure during Rheocarna therapy: A single-center case series
Takaya Handa1, Masaki Fujii2, Masumi Ando3
1Department of Nephrology and Dialysis, Medical Research Institute Kitano Hospital, PIIF Tazuke-Kofukai, Osaka, Japan.
Introduction:
A novel LDL (low-density lipoprotein) apheresis therapeutic option, Rheocarna, has garnered attention as an alternative therapy for chronic limb-threating ischemia (CLTI). Bradykinin-mediated vasodilation is involved in the effects of LDL apheresis and a decrease in blood pressure (BP), but the changes in bradykinin concentration during Rheocarna therapy are unknown.
Methods:
The study involved patients with CLTI treated with Rheocarna at our hospital, from April 2022 to August 2023.
Results:
After Rheocarna therapy, skin ulcers improved in 80% of the patients. Circuit coagulation was observed in two patients with high fibrinogen levels. A decrease in BP was observed at approximately the same time when the bradykinin concentration peaked. The peak bradykinin concentration in a patient undergoing hemodialysis at the same time was considerably lower than that in the other patients.
Conclusion:
This is the first report on the changes in bradykinin concentration under Rheocarna therapy.
Related Concept Videos
Assessment of blood pressure in brachial artery(two-step method)
Assessment of blood pressure in brachial artery(one-step method)
Prepare for the Procedure:
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Special considerations while measuring blood pressure
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Sites for measruring blood pressure
The Brachial Artery: Primary Site for Blood Pressure Measurement
Hypertension and Regulation of Blood Pressure

