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Association between the skin microbiome and lichen striatus hypopigmentation: Cutibacterium acnes as a potential
Yeuni Yu1, Byunghyuk Lee2, Kihyuk Shin2,3,4
1Biomedical Research Institute, School of Medicine, Pusan National University, Yangsan, Korea.
Background:
Lichen striatus (LS) is an acquired skin disorder with a linear pattern along Blaschko's lines. It commonly occurs in childhood, and the lesions spontaneously regress within several months.
Objectives:
Although up to 50% of LS cases exhibit hypopigmentation that can persist for several months to years, it is unknown why LS is associated with such a high incidence of hypopigmentation compared to other inflammatory skin diseases. Therefore, this study aimed to analyse the differences in the skin microbiome between LS patients with and without hypopigmentation.
Methods:
Differences in skin microbiome were analysed using whole genome sequencing of skin biopsies and subsequent bioinformatics analyses.
Results:
Some microbes commonly found in hypopigmented skin disorders, including Cutibacterium acnes, were more abundant in patients with LS showing hypopigmentation than in those not showing hypopigmentation.
Conclusions:
The skin microbiota may be involved in the development of hypopigmentation in LS and may be considered a treatment target to reduce LS duration and hypopigmentation.
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