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Association between type 1 diabetes mellitus and ankylosing spondylitis: a two-sample Mendelian randomization study
Ju Zhang1,2, Jiaping Qi2, Yixuan Li2
1Jinzhou Medical University Graduate Training Base Zhejiang Provincial People's Hospital, Center for General Practice Medicine, Department of Rheumatology and Immunology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China.
Frontiers in Immunology
|January 4, 2024
Summary
This study genetically linked Type 1 diabetes mellitus (T1DM) to an increased risk of ankylosing spondylitis (AS). Mendelian randomization analysis confirmed a causal relationship between T1DM and AS development.
Area of Science:
- Genetics
- Immunology
- Epidemiology
Background:
- Ankylosing spondylitis (AS) development is linked to autoimmune dysfunction.
- Type 1 diabetes mellitus (T1DM) is an autoimmune disease and a risk factor for other conditions.
Purpose of the Study:
- To investigate the potential causal genetic relationship between T1DM and AS.
- To utilize Mendelian randomization to assess T1DM as a risk factor for AS.
Main Methods:
- A two-sample Mendelian randomization (MR) study was conducted using genome-wide association study (GWAS) summary data.
- Inverse variance weighting (IVW) was the primary analysis method, supplemented by MR Egger, weighted median, and weighted mode.
- Sensitivity analyses included Cochran's Q test, MR-Egger intercept, and leave-one-out analysis to ensure robustness.
Main Results:
- Eleven single nucleotide polymorphisms (SNPs) were identified as instrumental variables for MR analysis.
- IVW analysis indicated a significant causal association between T1DM and AS (OR = 1.0006, p = 0.0057).
- Sensitivity analyses confirmed the stability and reliability of the results, with no significant horizontal pleiotropy detected.
Conclusions:
- The findings support a genetically determined causal relationship between T1DM and the risk of developing AS.
- This highlights T1DM as a potential risk factor contributing to AS pathogenesis.
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