Electroacupuncture for relieving itching in atopic eczema: study protocol for a multicenter, randomized,...

Area of Science:

• Dermatology
• Integrative Medicine
• Clinical Trials

Background:

• Atopic eczema (AE) is a prevalent inflammatory skin condition affecting millions globally.
• Pruritus (itching) is a debilitating symptom in AE, leading to a cycle of scratching and skin damage.
• Existing treatments for AE pruritus require further research for practical and safe options.

Purpose of the Study:

• To objectively evaluate the efficacy and safety of electroacupuncture (EA) for alleviating atopic eczema pruritus.
• To generate high-level clinical evidence supporting the use of EA in managing AE symptoms.

Main Methods:

• A multicenter, single-blinded, randomized controlled trial involving 132 participants with AE.
• Participants will be randomized into three groups: EA, sham electroacupuncture, and sham acupuncture.
• Treatment involves three sessions weekly for two weeks, with pruritus assessed using the Visual Analog Scale.

Main Results:

• Primary outcome: Visual Analog Scale for pruritus.
• Secondary outcomes: Eczema Area and Severity Index, Dermatology Life Quality Index, physical examination, serum IgE, and safety assessments.
• Adverse events will be meticulously recorded.

Conclusions:

• This study aims to provide robust evidence on the effectiveness of EA for AE-related itching.
• Findings will inform clinical practice regarding the application of EA as a therapeutic option for atopic eczema.