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Published on: June 23, 2015
Pedigree Analysis of Polycystic Kidney Disease Patients: Bangladeshi Perspective
Zohora Akther1, Samira Sultana Amee1, Md Mohiuddin Masum1
1Department of Anatomy, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Insights
Pedigree analysis in Bangladeshi Polycystic Kidney Disease (PKD) patients revealed a 63.2% family history, indicating vertical gene transmission. This method aids in early diagnosis and improved management of this inherited kidney disorder.
Area of Science:
- Genetics
- Nephrology
- Medical Diagnostics
Background:
- Polycystic kidney disease (PKD) is a significant inherited disorder.
- It is the fourth leading cause of end-stage renal disease.
- Pedigree analysis is a key diagnostic tool for inheritance patterns.
Purpose of the Study:
- To determine the type and frequency of PKD.
- To utilize pedigree analysis for diagnosing PKD in Bangladeshi patients.
Main Methods:
- A cross-sectional descriptive study was conducted.
- Thirty-eight adult Bangladeshi PKD patients were recruited.
- Pedigree analysis was performed using f-tree V4.0.6 software.
Main Results:
- 63.20% of patients had a positive family history.
- Vertical transmission was observed in all positive family history cases.
- Equal inheritance was noted between males and females, with specific instances of homozygous/heterozygous states, skipped generations, and male-to-male transmission.
Conclusions:
- Pedigree analysis is valuable for early diagnosis of PKD.
- It contributes to better disease management and prognosis.
- Understanding inheritance patterns is crucial for managing PKD.
Background:
Polycystic kidney disease (PKD), an inheritance disorder which is the fourth leading cause of the end-stage renal disease. The inheritance pattern can be diagnosed and confirmed by pedigree analysis. The aim of the present research was to determine the type and frequency of PKD using pedigree analysis.
Materials And Methods:
The present research was designed as a cross-sectional descriptive study. Thirty-eight adult Bangladeshi PKD patients were recruited using a selection checklist from the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Data were collected using a data collection sheet after taking informed written consent. The pedigree was drawn using the genetic pedigree chart creation software f-tree V4.0.6. The percentage frequencies of different types of pedigree were calculated using the Statistical Package for the Social Sciences software, version 23.
Results:
A total of 24 (63.20%) had a positive family history and 36.80% (14) had no positive family history. All of the patients with a positive family history had vertical transmission; male and female were equally inheriting the gene. Out of these 24 patients, 4.17% (one), 8.33% (two), and 16.67% (four) had a homozygous/heterozygous state, skip generation, and male to male transmission, respectively.
Conclusions:
Pedigree analysis of PKD patients showed an increased value in early diagnosis and better management and prognosis of the disease.
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