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[Neural networks in late life depression].

T Baert, T Vande Casteele, F Bouckaert

    Tijdschrift Voor Psychiatrie
    |January 4, 2024
    PubMed
    Summary

    Late-life depression (LLD) involves brain network changes, including structural alterations and accelerated aging, impacting treatment response. Neuroimaging reveals these neural network dysfunctions in LLD.

    Area of Science:

    • Neuroscience
    • Gerontology
    • Psychiatry

    Background:

    • Major depression is linked to neural network activity and connectivity changes.
    • Late-life depression (LLD) chronicity suggests structural brain changes contribute to network alterations.
    • Advanced brain imaging techniques allow multi-level investigation of neural networks in LLD.

    Conclusions:

    • Neuroimaging studies demonstrate diverse neurobiological changes contributing to neural network dysfunction in LLD.
    • Structural and functional brain alterations are key features of late-life depression.

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