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Within-host evolutionary dynamics and tissue compartmentalization during acute SARS-CoV-2 infection

Mireille Farjo1, Katia Koelle2, Michael A Martin2,3

  • 1Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

Journal of Virology
|January 4, 2024
PubMed
Summary

Daily sampling reveals SARS-CoV-2 evolution within hosts. Viral genetic changes were mostly random, but some variants transmitted, and distinct viral populations existed in saliva and nasal samples.

Keywords:
SARS-CoV-2genetic compartmentalizationviruseswithin-host evolution

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