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Published on: September 22, 2020
Impact of Low Bone Mineral Content Index on Cardiovascular Outcomes in Patients With Coronary Artery Disease
Tadashi Itagaki1, Yasushi Ueki2, Daisuke Sunohara2
1Department of Cardiology, Nagano Municipal Hospital, Japan.
Insights
Low bone mineral content index (BMCI) is a significant predictor of major adverse cardiovascular events (MACE) in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). This finding highlights BMCI as a potential prognostic marker for cardiovascular outcomes.
Area of Science:
- Cardiology
- Biomedical Engineering
- Clinical Outcomes Research
Background:
- The prognostic significance of bone mineral content (BMC) in patients with coronary artery disease (CAD) is not well-established.
- Assessing BMC may offer new insights into cardiovascular risk stratification.
Purpose of the Study:
- To investigate the association between the bone mineral content index (BMCI) and major adverse cardiovascular events (MACE) in patients with CAD undergoing percutaneous coronary intervention (PCI).
Main Methods:
- A cohort of 257 CAD patients undergoing PCI were analyzed between January 2020 and June 2021.
- BMCI was calculated using bioelectrical impedance analysis (BMC/height squared).
- Patients were stratified into low (<0.918) and high (≥0.918) BMCI groups based on receiver operating characteristic curve analysis for MACE.
Main Results:
- During a median follow-up of 744 days, the low BMCI group (n=152) exhibited a significantly higher incidence of MACE (19.7%) compared to the high BMCI group (n=105, 6.7%; P=.004).
- Multivariable Cox and Inverse Probability of Treatment Weighting analyses confirmed that low BMCI was a significant predictor of MACE (Hazard Ratio: 3.16; 95% Confidence Interval: 1.15-8.67; P=.025).
Conclusions:
- The bone mineral content index (BMCI) serves as a valuable predictor of cardiovascular events in patients with coronary artery disease undergoing PCI.
- Further investigation is warranted to explore therapeutic strategies targeting BMC to potentially enhance patient prognosis.
Abstract:
The prognostic value of bone mineral content (BMC) for the clinical outcomes of patients with coronary artery disease (CAD) remains unknown. The present study evaluated the association between BMC index (BMCI) and cardiovascular events between January 2020 to June 2021, in consecutive patients (n = 257) with CAD undergoing percutaneous coronary intervention (PCI) at the Nagano Municipal Hospital. BMCI was measured using bioelectrical impedance analysis and calculated as the BMC divided by height squared. Patients were classified as low (<0.918) or high BMCI (≥0.918) groups according to the receiver operating characteristics curve analysis for the primary endpoint, major adverse cardiovascular events (MACE), including cardiovascular death, spontaneous myocardial infarction, stroke, and any revascularization. During a median follow-up of 744 days, the low BMCI group (n = 152) had an increased risk of MACE compared with the high group (n = 105) (19.7 vs 6.7%, P = .004). A low BMCI was significantly associated with MACE in the multivariable Cox and the Inverse Probability of Treatment Weighting analyses (hazard ratio: 3.16, 95% confidence interval: 1.15-8.67, P = .025). In conclusion, among patients with CAD undergoing PCI, BMCI was a predictor for cardiovascular events. Further research is required to determine whether medical interventions for BMC can improve patient prognosis.
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