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Updated: Aug 1, 2026
Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
Published on: November 8, 2011
A case of clinically aggressive EBV-negative ENKTL in a non-Asian female patient
Thomas Kent1, Gregory Scott2, Robert Seifert2
1University of Florida College of Medicine, University of Florida, Gainesville, FL, USA. thomaskent@ufl.edu.
Background:
The patient was a 65-year-old White woman who presented to dermatology with a painless, rapidly growing exophytic nodule on her left upper cheek.
Aims/Purpose:
In this case report, we aim to demonstrate the difficulty of diagnosing Epstein-Barr virus-negative extranodal NK cell lymphomas given the broad differential of NK cell lymphomas and the rarity of EBV-negative extranodal NK cell lymphoma.
Methods:
Immunohistochemical studies confirmed the diagnosis of cutaneous, extranodal NK cell lymphoma. Interestingly, Epstein-Barr virus in situ hybridization was negative, which is unusual for most NK cell lymphomas.
Results/Conclusions:
In our view, a combination of immunohistochemistry, clonality assessment, sequencing, and flow cytometric studies is required.
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