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Updated: Jul 6, 2025

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
Iron-laden blasts in refractory acute myeloid leukemia
Christopher Vossen1, Roeun Im2, Pedro Horna2
1Department of Laboratory Medicine and Pathology, Division of Hematopathology, Mayo Clinic, 200 1st St SW, MN, 55905, Rochester, USA. vossen.christopher@mayo.edu.
Abstract:
We report a case of refractory acute myeloid leukemia with DEK-NUP214 rearrangement showing circulating monocytic blasts with abundant green cytoplasmic granules on the Wright-Giemsa stain. The granules were strongly positive for Perls' Prussian blue, consistent with hemosiderin deposits. This previously unreported finding is suggestive of siderophage activity by leukemic blasts, likely associated with monocytic differentiation.
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