Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Outliers and Influential Points01:08

Outliers and Influential Points

4.1K
An outlier is an observation of data that does not fit the rest of the data. It is sometimes called an extreme value. When you graph an outlier, it will appear not to fit the pattern of the graph. Some outliers are due to mistakes (for example, writing down 50 instead of 500), while others may indicate that something unusual is happening. Outliers are present far from the least squares line in the vertical direction. They have large "errors," where the "error" or residual is the...
4.1K
Critical Region, Critical Values and Significance Level01:16

Critical Region, Critical Values and Significance Level

11.9K
The critical region, critical value, and significance level are interdependent concepts crucial in hypothesis testing.
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in  probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
11.9K
The Anchoring-and-Adjustment Heuristic01:25

The Anchoring-and-Adjustment Heuristic

7.2K
In order to make good decisions, we use our knowledge and our reasoning. Often, this knowledge and reasoning is sound and solid. However, sometimes, we are swayed by biases or by others manipulating a situation. For example, let’s say you and three friends wanted to rent a house and had a combined target budget of $1,600. The realtor shows you only very run-down houses for $1,600 and then shows you a very nice house for $2,000. Might you ask each person to pay more in rent to get the...
7.2K
Critical Values01:31

Critical Values

6.9K
A critical value is a definite value obtained from a particular probability distribution at a predecided confidence level (or a predecided significance level) for a given population parameter. The critical value provides demarcation that separates the sample statistics that are likely to occur from the ones that are unlikely to occur based on the given probability distribution and the population parameter to be estimated. The critical value for normal distribution is obtained from the z...
6.9K
Regression Toward the Mean01:52

Regression Toward the Mean

6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Framing Effects03:26

Framing Effects

7.4K
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
7.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interpreting higher-order dependence in multimorbidity using cohort data: A partial information decomposition approach.

PLoS computational biology·2026
Same author

Reply - RE: Policy Versus Practice: Facilitators and Barriers of Chronic Care Integration in Dutch General Practice - a Survey Study.

International journal of integrated care·2026
Same author

Effectiveness of prehabilitation modalities before total hip arthroplasty: a systematic review and network meta-analysis.

Annals of physical and rehabilitation medicine·2026
Same author

Evaluating dementia risk prediction in mild cognitive impairment: an early health technology assessment of the AI-Mind tool.

GeroScience·2026
Same author

Positive predictive value of Dutch Elder Abuse Scale (ERASE): an early warning tool for elder abuse in the emergency department and geriatric outpatient setting.

BMC geriatrics·2025
Same author

Usability and Concurrent Validity of the Gamified Brain Aging Monitor of Cognition (BAMCOG) for the Self-Monitoring of Perioperative Cognitive Function: A Pilot Study.

Brain sciences·2025
Same journal

[Insulin intoxications caused by falsified semaglutide].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[Professional skepticism in medical research].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[Improving mobility in painful osteoarthritis].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[The effectiveness and costs of the Back At work After Surgery (BAAS) work-integrated care pathway on return to work for patients receiving knee arthroplasty].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[The rise of genetic therapies: urgent moral and societal questions].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[A man with a wound on his elbow].

Nederlands tijdschrift voor geneeskunde·2026
See all related articles

Related Experiment Video

Updated: Jul 6, 2025

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions
07:34

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions

Published on: March 25, 2014

9.9K

[What do you mean by 'tipping point'?]

Marten Scheffer1,2, Marcel G M Olde Rikkert3

  • 1Wageningen University, afd. Aquatische ecologie en kwaliteit van watermanagement, Wageningen.

Nederlands Tijdschrift Voor Geneeskunde
|January 4, 2024
PubMed
Summary
This summary is machine-generated.

Complex adaptive systems, including living organisms, exhibit critical slowing near tipping points. Quantified frailty and resilience predict system dynamics and recovery from disease or stress.

More Related Videos

A Tactile Automated Passive-Finger Stimulator TAPS
19:44

A Tactile Automated Passive-Finger Stimulator TAPS

Published on: June 3, 2009

13.7K
Tactile Semiautomatic Passive-Finger Angle Stimulator TSPAS
04:40

Tactile Semiautomatic Passive-Finger Angle Stimulator TSPAS

Published on: July 30, 2020

2.9K

Related Experiment Videos

Last Updated: Jul 6, 2025

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions
07:34

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions

Published on: March 25, 2014

9.9K
A Tactile Automated Passive-Finger Stimulator TAPS
19:44

A Tactile Automated Passive-Finger Stimulator TAPS

Published on: June 3, 2009

13.7K
Tactile Semiautomatic Passive-Finger Angle Stimulator TSPAS
04:40

Tactile Semiautomatic Passive-Finger Angle Stimulator TSPAS

Published on: July 30, 2020

2.9K

Area of Science:

  • Physiology
  • Complex Systems Science
  • Ecology

Context:

  • Homeostatic balance is crucial for all living organisms.
  • Diseases and external stressors disrupt this balance, potentially leading to disease states.
  • Tipping points are observed in various complex systems, including financial and healthcare institutions during crises.

Purpose:

  • To elucidate the behavior of complex adaptive systems near tipping points.
  • To explore the concepts of frailty and resilience in characterizing system dynamics.
  • To quantify frailty and resilience for prognostic value.

Summary:

  • Complex adaptive systems demonstrate critical slowing as they approach tipping points.
  • Frailty quantifies the risk of crossing tipping points, while resilience measures the ability to return to a balanced state.
  • Both frailty and resilience can be quantified and offer predictive insights into system dynamics.

Impact:

  • Understanding tipping points enhances our ability to predict and manage system transitions.
  • Quantifying frailty and resilience provides valuable prognostic tools for biological and non-biological systems.
  • This research contributes to a broader understanding of system stability and recovery mechanisms across disciplines.