Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Erythrocytes01:27

Disorders of Erythrocytes

945
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
945
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

3.3K
The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
3.3K
Erythropoiesis01:14

Erythropoiesis

4.3K
Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
4.3K
Disorders of Hemostasis01:24

Disorders of Hemostasis

922
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
922
Multiple Allele Traits01:49

Multiple Allele Traits

34.2K
The Concept of Multiple Allelism
34.2K
Anorexia Nervosa01:28

Anorexia Nervosa

73
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
73

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Noninvasive prenatal testing in CLL during pregnancy: A cautionary tale.

EJHaemยท2025
Same author

Type of D-dimer assay determines the diagnostic yield of computed tomography in patients suspected for pulmonary embolism.

Research and practice in thrombosis and haemostasisยท2025
Same author

Fulminant intravascular hemolysis resulting from Clostridium perfringens infection.

American journal of hematologyยท2024
Same author

Use and Waste of Reconstituted Whole Blood Exchange Transfusions: An 11-year National Observational Study.

The Journal of pediatricsยท2024
Same author

Machine Learning-Based Prediction of Hemoglobinopathies Using Complete Blood Count Data.

Clinical chemistryยท2024
Same author

High-throughput Proteomics Identifies THEMIS2 as Independent Biomarker of Treatment-free Survival in Untreated CLL.

HemaSphereยท2023

Related Experiment Video

Updated: Jul 6, 2025

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes
08:53

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes

Published on: January 10, 2025

498

[Normocytic anaemia due to multiple causes].

Jorn L J C Assmann1,2, Floor Weerkamp1

  • 1Maasstad Ziekenhuis, afd. Klinische Chemie, Rotterdam.

Nederlands Tijdschrift Voor Geneeskunde
|January 4, 2024
PubMed
Summary

Diagnosing anemia can be complex, as seen in a case with both beta thalassemia trait and myelodysplastic syndrome. Manual blood smear review proved crucial for accurate diagnosis.

Area of Science:

  • Hematology
  • Clinical Pathology

Background:

  • Anemia classification into microcytic, normocytic, and macrocytic categories guides etiological investigation.
  • Accurate diagnosis is essential for appropriate patient management and treatment.

Observation:

  • A 73-year-old male presented with normocytic anemia.
  • Initial presentation suggested a diagnostic challenge due to coexisting conditions.

Findings:

  • The patient exhibited characteristics of both beta thalassemia trait (microcytic) and myelodysplastic syndrome (typically macrocytic).
  • This combination resulted in a heterogeneous red blood cell population, leading to a normal mean corpuscular volume (MCV).
  • Manual peripheral blood smear differentiation was instrumental in resolving the diagnostic ambiguity.

More Related Videos

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
12:05

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Published on: November 3, 2018

11.7K
Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay
15:32

Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay

Published on: August 5, 2011

32.4K

Related Experiment Videos

Last Updated: Jul 6, 2025

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes
08:53

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes

Published on: January 10, 2025

498
Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
12:05

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Published on: November 3, 2018

11.7K
Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay
15:32

Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay

Published on: August 5, 2011

32.4K

Implications:

  • This case highlights the limitations of automated indices in complex anemia.
  • Emphasizes the continued importance of manual microscopy in hematological diagnostics.
  • Suggests a need for careful consideration of combined pathologies in unexplained anemia.