Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Special Features of Adaptive Immunity

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Vaccinations

Vaccinations

Antigens Involved in Adaptive Immunity

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

Immunological Memory

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A myeloid Tet2-IL-1β axis modulates intestinal inflammation by restricting catecholaminergic stimulation of enterochromaffin cell differentiation.

Immunity·2025

Same author

Gut mucosal immune responses - Implications for celiac disease and food allergy.

Seminars in immunology·2025

Same author

A dendritic cell population responsible for transglutaminase 2-mediated gluten antigen presentation in celiac disease.

JCI insight·2025

Same author

A dendritic cell population responsible for transglutaminase 2-mediated gluten antigen presentation in celiac disease.

bioRxiv : the preprint server for biology·2025

Same author

Microbes with higher metabolic independence are enriched in human gut microbiomes under stress.

eLife·2025

Same author

A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection.

Cell·2025

Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026

Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026

Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026

Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026

Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026

Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 6, 2025

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Restoring tolerance with antigen delivery.

Bana Jabri^1,2,3,4, Valérie Abadie^1,2,3

¹Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Department of Medicine, Chicago, IL, USA.

Science (New York, N.Y.)

|January 4, 2024

Summary

This summary is machine-generated.

New strategies are being developed to control autoimmune diseases by precisely delivering antigens. This approach aims to retrain the immune system and reverse harmful autoimmune responses.

More Related Videos

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells

Published on: March 5, 2019

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

Related Experiment Videos

Last Updated: Jul 6, 2025

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells

Published on: March 5, 2019

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

Area of Science:

Immunology
Autoimmune Diseases
Therapeutic Strategies

Background:

Autoimmune diseases involve immune system attacks on the body's own tissues.
Current treatments often broadly suppress the immune system, leading to side effects.
Modulating antigen delivery offers a targeted approach to restore immune tolerance.

Purpose of the Study:

To investigate novel strategies for antigen delivery in autoimmune conditions.
To evaluate the potential of antigen modulation to reverse established autoimmunity.
To explore mechanisms by which targeted antigen delivery can re-educate immune responses.

Main Methods:

Developing methods for controlled delivery of specific antigens.
Testing these strategies in preclinical models of autoimmunity.
Assessing immune cell responses and disease markers post-treatment.

Main Results:

Demonstrated successful modulation of antigen delivery to target immune cells.
Observed reversal of autoimmune pathology in experimental models.
Identified specific immune pathways affected by antigen modulation.

Conclusions:

Antigen delivery modulation is a promising therapeutic avenue for autoimmune diseases.
Targeted antigen delivery can induce immune tolerance and reverse autoimmunity.
Further research is warranted to translate these findings into clinical applications.