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Irisin: An unveiled bridge between physical exercise and a healthy brain
Najwane Said Sadier1, Farah El Hajjar2, Amani Al Khayat Al Sabouri2
1College of Health Sciences, Abu Dhabi University, Al Ain Road, Abu Dhabi, PO Box 3838-111188, United Arab Emirates; Neurosciences Research Center, Faculty of Medical Sciences, Lebanese University, 275 Old Saida Road, Beirut, PO Box 6573/14, Lebanon.
Life Sciences
|January 4, 2024
Summary
Irisin, a protein induced by exercise, shows neuroprotective effects in animal studies. Injections reduced neuroinflammation and neurodegeneration, highlighting its potential for brain health.
Area of Science:
- Neuroscience
- Exercise Physiology
- Molecular Biology
Background:
- Physical exercise benefits brain health, improving cognition and mood.
- Irisin, an exercise-induced myokine, crosses the blood-brain barrier and may mediate these effects.
- This review focuses on Irisin's role in neuroprotection against inflammation and degeneration.
Approach:
- Systematic review of animal trials.
- Searched PubMed, Embase, and Google Scholar databases.
- Assessed study quality using SYRCLE's Risk of Bias tool.
Key Points:
- Twelve studies confirmed Irisin injection reduced neuroinflammation and neurodegeneration in rodents.
- Irisin protected neurons, decreased oxidative stress, and improved neurobehavioral deficits.
- Multiple mechanisms underlie Irisin's neuroprotective potential.
Conclusions:
- Irisin injection demonstrates significant neuroprotective effects in animal models.
- Further research is needed to elucidate mechanisms and clinical applications.
- Irisin holds promise for treating neuroinflammatory and neurodegenerative diseases.
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