Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Liver Physiology01:30

Liver Physiology

561
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
561

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tau-ing and fro-ing: the tanycytic shuttle in neurodegeneration.

The journal of prevention of Alzheimer's disease·2026
Same author

Metabolic state determines the brain and direct islet effects of liraglutide on enhanced insulin secretion.

Diabetologia·2026
Same author

A synaptoid connectome differentiates tanycytic subpopulations and underlies neuroglial communication and neuroendocrine regulation.

Nature communications·2026
Same author

Tanycytic degeneration impairs tau clearance and contributes to Alzheimer's disease pathology.

Cell press blue·2026
Same author

Brain endothelial Gα<sub>q/11</sub> signalling in cerebrovascular function and cognition of aged mice.

EBioMedicine·2026
Same author

Hepatocyte Circadian Clocks Control Cholesterol Metabolism and Protect From Metabolic Dysfunction-Associated Steatohepatitis.

Cellular and molecular gastroenterology and hepatology·2026

Related Experiment Video

Updated: Jul 6, 2025

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse
08:27

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

Published on: July 25, 2011

19.7K

Liver Metabolism in Ischemic Stroke.

Julica Inderhees1, Markus Schwaninger2

  • 1Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism, University of Lübeck, Lübeck, Germany; German Research Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, Germany; Bioanalytic Core Facility, Center of Brain, Behavior and Metabolism, University of Lübeck, Lübeck, Germany.

Neuroscience
|January 4, 2024
PubMed
Summary
This summary is machine-generated.

Acute ischemic stroke (AIS) affects the brain and triggers systemic inflammation. Targeting liver metabolism, particularly lipid and glucose pathways, may offer new therapeutic strategies to improve patient outcomes after stroke.

Keywords:
glutathionehepatic metabolismischemic strokeliver

More Related Videos

An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke
12:19

An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke

Published on: March 11, 2018

11.4K
Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
10:31

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Published on: December 28, 2014

14.0K

Related Experiment Videos

Last Updated: Jul 6, 2025

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse
08:27

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

Published on: July 25, 2011

19.7K
An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke
12:19

An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke

Published on: March 11, 2018

11.4K
Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
10:31

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Published on: December 28, 2014

14.0K

Area of Science:

  • Neuroscience
  • Immunology
  • Metabolic Medicine

Background:

  • Acute ischemic stroke (AIS) causes focal brain damage and neurological deficits.
  • Cerebral ischemia leads to systemic alterations, including immune response dysregulation and inflammation.
  • The liver plays a critical role in post-stroke systemic effects, influencing immunosuppression and hyperglycemia.

Purpose of the Study:

  • To review recent findings on the relationship between ischemic stroke and liver function.
  • To discuss the liver's contribution to systemic alterations following AIS.
  • To explore the therapeutic potential of targeting hepatic metabolism for stroke recovery.

Main Methods:

  • Literature review of recent studies on acute ischemic stroke and liver metabolism.
  • Analysis of the interplay between hepatic metabolic pathways (glucose, lipid) and systemic inflammation post-stroke.
  • Examination of the role of ketogenesis, glutathione, and VLDL secretion in the context of AIS.

Main Results:

  • The liver contributes to post-stroke immunosuppression and stress-induced hyperglycemia.
  • Increased hepatic ketogenesis and glutathione production may combat inflammation and oxidative stress.
  • Hepatic lipid metabolism, including VLDL secretion, influences glucose and glutathione homeostasis, potentially improving availability of key molecules like phospholipids and PUFAs.

Conclusions:

  • Targeting hepatic metabolism presents a promising therapeutic avenue for improving patient outcomes after acute ischemic stroke.
  • Understanding the liver's role in regulating systemic inflammation and metabolic homeostasis is crucial for developing novel stroke treatments.
  • Further research into hepatic lipid and glucose metabolism could uncover new strategies to mitigate the systemic consequences of AIS.