Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...

The Endocrine System

The Endocrine System

The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...

Major Hormones and Their Functions

Major Hormones and Their Functions

Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026

Same author

Shared Epitope-Positive <i>HLA</i> Alleles Protect Against Alpha-Synuclein Pathology in a Model of Parkinson Disease.

Neurology(R) neuroimmunology & neuroinflammation·2026

Same author

Conditional deletion of the multiple sclerosis susceptibility gene ATXN1 identifies cell-autonomous effects in the B-cell compartment.

The FEBS journal·2025

Same author

SARS-CoV-2 infection of substantia nigra pars compacta induces expression of miR-330-5p at 10 days post-infection.

The Journal of general virology·2025

Same author

Loss of ADAP1/CentA1 Protects Against Autoimmune Demyelination.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2025

Same author

Adamts9 is required for the development of primary ovarian follicles and maintenance of female sex in zebrafish†.

Biology of reproduction·2024

Same journal

The Wiskott-Aldrich Syndrome protein (WASp) contribution to microglial phagocytic function and neurodevelopmental support.

Journal of neuroinflammation·2026

Same journal

Targeting the cGAS-STING pathway alleviates neuroinflammation and cognitive impairment induced by chronic infection of Toxoplasma gondii.

Journal of neuroinflammation·2026

Same journal

Dysregulated glia and periglomerular cells in the olfactory bulb and altered lipocalins in the olfactory epithelium underlie olfactory dysfunction in a murine model of eosinophilic chronic rhinosinusitis.

Journal of neuroinflammation·2026

Same journal

Human umbilical cord blood mononuclear cells ameliorate vascular dementia by modulating microglial myelin debris handling and white matter injury.

Journal of neuroinflammation·2026

Same journal

Neuron-specific deletion of ADAR1 induces brain malformation and early postnatal lethality.

Journal of neuroinflammation·2026

Same journal

Regional mapping of CSF1R-positive microglia in neurodegenerative diseases and progressive MS, with exploratory presynaptic marker analyses.

Journal of neuroinflammation·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 6, 2025

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Autoimmune demyelination alters hypothalamic transcriptome and endocrine function.

Jonathan J Carver¹, Kristy M Lau¹, Alexandra E Puckett¹

¹Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, 600 Moye Blvd., Greenville, NC, USA.

Journal of Neuroinflammation

|January 4, 2024

Summary

This summary is machine-generated.

The hypothalamus plays a key role in maintaining body balance, and its dysfunction is linked to multiple sclerosis (MS) symptoms. This study reveals hypothalamic changes during experimental autoimmune encephalomyelitis, an MS model, highlighting its central role in CNS autoimmunity.

Keywords:

Endocrine system Experimental autoimmune encephalomyelitis Hypothalamus Multiple sclerosis

More Related Videos

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Related Experiment Videos

Last Updated: Jul 6, 2025

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Area of Science:

Neuroscience
Immunology
Endocrinology

Background:

The hypothalamus regulates homeostasis via autonomic and hormonal functions.
Hypothalamic dysfunction causes symptoms seen in multiple sclerosis (MS).
Altered hormone levels in MS patients suggest hypothalamic involvement.

Purpose of the Study:

To systematically analyze hypothalamic function during neuroinflammation.
To investigate hypothalamic transcriptome changes in an MS model.

Main Methods:

Longitudinal transcriptomic profiling of the hypothalamus.
Utilized experimental autoimmune encephalomyelitis (EAE), a murine MS model.

Main Results:

Observed anti-inflammatory gene expression changes starting pre-disease onset and persisting.
Detected altered hypothalamic neuropeptides linked to stress and feeding behaviors.
Identified defects in steroidogenic pathways of endocrine glands.

Conclusions:

Hypothalamic dysfunction is central to central nervous system (CNS) autoimmunity.
Findings support the hypothalamus's critical role in MS pathogenesis and manifestations.