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Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

244
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
244
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

240
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
240

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Causal relationship between gut microbiota and tuberculosis: a bidirectional two-sample Mendelian randomization

Zongxiang Yuan1, Yiwen Kang1, Chuye Mo1

  • 1Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning, 530021, China.

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Area of Science:

  • Microbiome research
  • Infectious disease epidemiology
  • Genetic epidemiology

Background:

  • Observational studies suggest a link between gut microbiota and tuberculosis (TB).
  • Causality and bidirectionality between gut microbiota and TB remain unclear.

Purpose of the Study:

  • To investigate the causal relationship between gut microbiota and TB using a bidirectional Mendelian randomization approach.
  • To identify specific bacterial taxa associated with TB risk and its phenotypes.

Main Methods:

  • Bidirectional two-sample Mendelian randomization (MR) analysis.
  • Utilized GWAS summary statistics for 195 bacterial taxa from the MiBioGen consortium.
  • Employed various MR methods (IVW, MR-Egger, etc.) and robustness tests (heterogeneity, pleiotropy).

Main Results:

  • Identified 11 bacterial taxa with potential causal effects on TB in the UK Biobank.
  • Validated three taxa (Akkermansia, Verrucomicrobiacea, Verrucomicrobiales) in the FinnGen database.
  • Found distinct gut microbial profiles for respiratory TB (RTB) and extrapulmonary TB (EPTB), with specific taxa linked to increased or decreased risk.

Conclusions:

  • Established a one-way causal relationship: gut microbiota influences TB development.
  • Highlighted specific gut bacteria as potential targets for TB prevention, diagnosis, and therapy.