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The promise and challenges of combination therapies with antibody-drug conjugates in solid tumors

Qing Wei1,2,3, Peijing Li2,4, Teng Yang2,5

  • 1Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, China.

Journal of Hematology & Oncology
|January 4, 2024
PubMed

Insights

Antibody-drug conjugates (ADCs) show promise in cancer therapy. This review examines ADC combinations with other treatments, detailing mechanisms, benefits, and challenges for improved solid tumor treatment.

Area of Science:

  • Oncology
  • Pharmacology
  • Cancer Therapeutics

Background:

  • Antibody-drug conjugates (ADCs) have transformed solid tumor treatment.
  • Combination therapies involving ADCs are under extensive investigation.
  • Potential for synergistic effects but also overlapping toxicities necessitates further understanding.

Purpose of the Study:

  • To comprehensively review the current evidence on ADC combination therapy.
  • To analyze the additive or synergistic effects of ADCs with other oncology drugs.
  • To elucidate the underlying biological mechanisms and assess benefits and challenges.

Main Methods:

  • Systematic review of existing preclinical and clinical studies on ADC combinations.
  • Analysis of biological mechanisms driving different ADC combination strategies.
  • Evaluation of prominent examples, their benefits, and associated challenges.

Main Results:

  • Combination therapy with ADCs does not consistently yield synergistic or additive effects.
  • Overlapping toxicity risks are a significant consideration in ADC combination regimens.
  • Diverse biological mechanisms underlie the efficacy and toxicity of ADC combinations.

Conclusions:

  • Understanding ADC combination mechanisms is crucial for optimizing cancer treatment.
  • Careful assessment of benefits versus risks is needed for successful clinical application.
  • Future research should focus on novel strategies to maximize ADC combination therapy potential.
Keywords:
Antibody-drug conjugateCombination therapyImmunotherapySolid tumorTargeted therapy

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