Patient experiences with tissue-based genomic testing during active surveillance for prostate cancer

Area of Science:

• Oncology
• Genetics
• Patient Experience Research

Background:

• Tissue-based genomic tests assess prostate cancer aggressiveness.
• These tests are increasingly used for patients on active surveillance.
• Little is known about patient experiences and decision-making roles regarding genomic testing.

Purpose of the Study:

• To explore patient experiences with genomic testing during prostate cancer management.
• To understand the role of genomic testing in decision-making for active surveillance.
• To identify patient understanding and misconceptions regarding genomic test results.

Main Methods:

• Qualitative study using in-depth, semi-structured interviews with 20 patients on active surveillance.
• Purposive sampling for patients who received biopsy-based genomic testing.
• Conventional content analysis of interview data until thematic saturation.

Main Results:

• Genomic testing decisions were influenced by both patients and physicians; some patients were unaware testing occurred.
• Test results increased patient confidence in active surveillance decisions.
• Patients showed misconceptions distinguishing tissue-based from germline tests, believing the former indicated hereditary risk. Communication varied, with some finding explanations limited.

Conclusions:

• Patient interaction with and influence by biopsy-based genomic testing results are significant during active surveillance.
• Gaps in understanding test results highlight the need for improved patient counseling.
• Enhanced patient knowledge and comfort with genomic testing are crucial for effective shared decision-making.