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Related Experiment Video

Updated: Jul 6, 2025

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

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Published on: October 6, 2023

416

Thyroid function, renal function, and depression: an association study.

Hai Liang1,2, Jin-Min Wang1, Xiao-Qian Wei3

  • 1Department of Neurology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, China.

Frontiers in Psychiatry
|January 5, 2024
PubMed
Summary
This summary is machine-generated.

Major depressive disorder (MDD) is linked to lower thyroid and renal function, indicating reduced intake and metabolism. Anion gap fluctuations correlate with depression and anxiety severity in MDD patients.

Keywords:
anion gapanxiety disordersdepressive disorderrenal function teststhyroid function tests

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Area of Science:

  • Endocrinology
  • Nephrology
  • Psychiatry

Background:

  • Thyroid and renal dysfunctions are increasingly recognized as potential contributors to mood disorders.
  • Understanding these physiological links may offer new insights into the pathophysiology of Major Depressive Disorder (MDD).

Purpose of the Study:

  • To investigate the correlations between thyroid function, renal function, and depression severity.
  • To identify potential biomarkers for depression and anxiety within these physiological parameters.

Main Methods:

  • Retrospective analysis of clinical data from 67 MDD patients and 36 healthy controls.
  • Comparison of thyroid and renal function tests between groups.
  • Spearman correlation and logistic regression analyses to assess relationships between physiological markers and depression/anxiety scores (HAMD, HAMA).

Main Results:

  • MDD patients exhibited lower levels of T3, T4, FT3, uric acid, sodium, and anion gap compared to controls.
  • TSH correlated positively with diurnal variation, hopelessness, and depression level.
  • Creatinine correlated negatively with cognitive disturbance, retardation, and depression level.
  • Anion gap showed significant correlations with depression and anxiety symptoms, identified as an independent risk factor.

Conclusions:

  • Reduced thyroid function and impaired renal waste metabolism are observed in MDD patients, suggesting decreased intake and metabolism.
  • Anion gap fluctuations are strongly associated with the severity of depression and anxiety in individuals with MDD.