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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Updated: Jul 6, 2025

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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[Senile atopic dermatitis - current vision and unresolved issues.]

I O Smirnova1, P D Ptashnikova1, M S Ten2

  • 1Saint-Petersburg State University, 8a V.O. line 21, St. Petersburg 199106, Russian Federation,

Advances in Gerontology = Uspekhi Gerontologii
|January 5, 2024
PubMed
Summary
This summary is machine-generated.

Senile atopic dermatitis (AD) in individuals over 60 presents unique challenges due to aging skin and overall health. This review explores its epidemiology, pathogenesis, and tailored treatment strategies for this demographic.

Keywords:
atopic dermatitisdupilumabimmune dysfunctionmicrobiomesenile atopic dermatitisskin agingskin barrier

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Area of Science:

  • Dermatology
  • Geriatrics
  • Immunology

Context:

  • Atopic dermatitis (AD) is a common skin condition with complex causes.
  • Aging affects skin barrier and immune functions, potentially altering AD presentation and severity in older adults.
  • The concept of 'senile AD' in patients over 60 requires specific consideration due to age-related physiological changes.

Purpose:

  • To review and synthesize current knowledge on the epidemiology, pathogenesis, clinical features, and treatment of atopic dermatitis in elderly and senile populations.
  • To highlight the unique aspects of AD in older adults, including age-related skin changes and comorbidities.
  • To identify gaps in research and suggest future directions for understanding and managing AD in the elderly.

Summary:

  • Epidemiological data on AD incidence in the elderly are limited and inconsistent.
  • Pathogenesis in senile AD involves synergistic skin barrier and immune dysfunction, often leading to more severe disease.
  • Factors like comorbidities, polypharmacy, lifestyle, and inadequate skincare significantly influence AD course in older patients.

Impact:

  • This review provides a comprehensive overview of atopic dermatitis in elderly patients, addressing a gap in the literature.
  • It emphasizes the need for adapted diagnostic and therapeutic approaches for senile AD.
  • Findings can guide clinicians in managing this specific patient group and inform future research priorities.