Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasmapheresis in acute liver failure.

J G Freeman, K Matthewson, C O Record

    The International Journal of Artificial Organs
    |November 1, 1986
    PubMed
    Summary

    Daily plasmapheresis improved coma grade in 77% of acute hepatic failure patients, with 55% surviving. This procedure offers a simple, effective temporary hepatic support option warranting further investigation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Autoimmune pancreatitis presenting as a pancreatic mass mimicking malignancy.

    Singapore medical journal·2011
    Same author

    Poor tolerability of thalidomide in end-stage oesophageal cancer.

    European journal of cancer care·2011
    Same author

    Cholestasis and biliary dilatation associated with chronic ketamine abuse: a case series.

    Singapore medical journal·2011
    Same author

    Hepatic encephalopathy after transjugular intrahepatic portosystemic shunt insertion: a decade of experience.

    QJM : monthly journal of the Association of Physicians·2008
    Same author

    A framework convention on alcohol control.

    Lancet (London, England)·2007
    Same author

    Hepatitis C virus genotypes in a cohort of Middle Eastern patients.

    Annals of Saudi medicine·2007

    Area of Science:

    • Hepatology
    • Critical Care Medicine

    Background:

    • Acute hepatic failure is a critical condition with high mortality.
    • Grade IV hepatic coma indicates severe neurological impairment.
    • Current treatment options for acute hepatic failure are limited.

    Purpose of the Study:

    • To evaluate the efficacy of plasmapheresis in patients with acute hepatic failure and Grade IV hepatic coma.
    • To assess the impact of plasmapheresis on coma grade, survival rates, and key biochemical markers.

    Main Methods:

    • A series of 9 patients with acute hepatic failure and Grade IV hepatic coma underwent daily plasmapheresis.
    • Treatment continued until patient recovery or death.
    • Outcomes including coma grade, survival, and serum markers were monitored.

    Main Results:

    • Seven out of nine patients (77%) showed improvement in their coma grade.
    • Five patients (55%) survived and were discharged from the hospital.
    • Plasmapheresis significantly reduced serum bilirubin, aspartate aminotransferase, and plasma ammonia levels.

    Conclusions:

    • Plasmapheresis demonstrated significant biochemical improvements and improved survival rates in patients with acute hepatic failure.
    • The procedure is simple and appears effective, suggesting it as a viable temporary hepatic support.
    • Further research is indicated to validate plasmapheresis as a therapeutic option for acute hepatic failure.

    Related Experiment Videos