Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

3.6K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.6K
Telomeres and Telomerase02:41

Telomeres and Telomerase

23.4K
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
23.4K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.4K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

11.5K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.5K
Dihybrid Crosses01:18

Dihybrid Crosses

74.9K
Overview
74.9K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

15.1K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interactive effects of biochar, nitrogen fertilizer, and irrigation on SOC and crop yield in a rice-wheat rotation system.

Frontiers in plant science·2026
Same author

Short-term efficacy of increasing 0.01% atropine administration frequency in controlling myopia progression in adolescents.

BMC ophthalmology·2026
Same author

Exposure to Ketamine and 2-Fluorodeschloroketamine Impairs Mitochondrial Oxidative Phosphorylation in Human Cerebral Organoids: Implications for Neurodevelopmental Toxicity.

Current neuropharmacology·2026
Same author

From bioinformatics to bedside: PPBP drives glioblastoma progression under hypoxia via CXCR2/PI3K/Akt signaling and is targetable by Oenothein B.

Cancer cell international·2026
Same author

The Elevational Distribution Patterns and Driving Factors of Plant Carbon Storage Across Different Functional Groups in Subalpine Grasslands of the Eastern Loess Plateau, China.

Plants (Basel, Switzerland)·2026
Same author

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Related Experiment Video

Updated: Jul 6, 2025

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
11:44

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

Published on: March 22, 2024

1.7K

Causal association between telomere length and colorectal polyps: A bidirectional two-sample Mendelian randomization

Yin Zhang1, Jiaying Wang, Mingyu Zheng

  • 1Department of General Surgery, Aerospace Center Hospital, Beijing, China.

Medicine
|January 5, 2024
PubMed
Summary

Longer telomere length (TL) is causally linked to an increased risk of colorectal polyps. This finding suggests TL may serve as a potential biomarker for polyp screening and prevention strategies.

More Related Videos

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

46.5K
Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq
09:52

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq

Published on: April 19, 2013

24.4K

Related Experiment Videos

Last Updated: Jul 6, 2025

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
11:44

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

Published on: March 22, 2024

1.7K
Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

46.5K
Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq
09:52

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq

Published on: April 19, 2013

24.4K

Area of Science:

  • Genetics and Epidemiology
  • Cancer Research
  • Molecular Biology

Background:

  • Telomere length (TL) is a key indicator of cellular aging and has been implicated in various diseases.
  • Colorectal polyps are common precursors to colorectal cancer, necessitating effective screening and prevention methods.

Purpose of the Study:

  • To investigate the potential causal relationship between telomere length and the risk of developing colorectal polyps using a robust genetic approach.
  • To explore whether telomere length can be utilized as a predictive biomarker for colorectal polyp formation.

Main Methods:

  • A bidirectional two-sample Mendelian randomization (MR) design was employed, utilizing genome-wide association study summary data for TL and colorectal polyps.
  • One hundred and twenty-four single nucleotide polymorphisms (SNPs) at a genome-wide significance threshold (P < 5 × 10⁻⁸) served as instrumental variables.
  • Causal inference was performed using inverse variance weighted, MR-Egger, and weighted median methods, with sensitivity analyses including Cochran's Q test and leave-one-out analyses to assess pleiotropy.

Main Results:

  • A significant causal association was identified between telomere length and colorectal polyps.
  • Longer telomere length was found to increase the risk of colorectal polyps, with consistent findings across different MR methods (e.g., OR: 1.008, 95% CI: 1.004-1.012 for one dataset).
  • Sensitivity analyses confirmed the robustness of the observed causal link, indicating minimal impact from pleiotropy.

Conclusions:

  • The study provides evidence for a causal association where longer telomere length elevates the risk of colorectal polyps.
  • Telomere length emerges as a potential biomarker for colorectal polyp screening and prevention.
  • Further validation studies are recommended to confirm these findings and their clinical implications.