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Serotonin and haemorrheology.

J A Dormandy

    International Journal of Cardiology
    |February 1, 1987
    PubMed
    Summary

    Blood flow (rheology) is vital for tissue perfusion. White blood cell deformability and serotonin

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    Area of Science:

    • Hematology
    • Physiology
    • Biomedical Engineering

    Background:

    • Tissue perfusion relies heavily on blood rheology, particularly the deformability of cellular components in microcirculation.
    • While red blood cell deformability was previously considered paramount, white blood cell rheology is now recognized as equally important.
    • Evidence links blood microrheological properties to tissue ischemia, with a potential role for serotonin.

    Purpose of the Study:

    • To explore the role of serotonin in altering blood rheology.
    • To investigate the effects of serotonin antagonists, like ketanserin, on blood filterability and cellular deformability.

    Main Methods:

    • Utilized studies involving specific serotonin antagonists.
    • Administered ketanserin orally to patients with myocardial infarction and intermittent claudication.
    • Assessed improvements in blood filterability and specific effects on white blood cells.

    Main Results:

    • Ketanserin improved blood filterability in patients with myocardial infarction and intermittent claudication.
    • Ketanserin demonstrated a specific beneficial effect on white blood cells.
    • Findings suggest serotonin may negatively impact blood cell rheology.

    Conclusions:

    • Serotonin's effect on blood cell rheology may perpetuate tissue ischemia, especially when local plasma serotonin levels increase.
    • Serotonin antagonists like ketanserin show promise in improving blood rheology and potentially mitigating ischemia.

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