Plasma concentrations of ketanserin in chronic hemodialysed patients

Six patients on chronic hemodialysis received 20 mg ketanserin p.o. twice daily for 3 days. Plasma levels were measured daily 2 hours after application of the morning dose; however, on the third day, plasma levels were taken before, during and after dialysis. On the 4th day elimination was measured after a single dose of 20 mg ketanserin for 24 hours. Mean plasma levels ranged from 19 to 31 ng/ml. Both ketanserin and reduced ketanserin were not eliminated by dialysis. Elimination half-life was about 12 hours.