Related Experiment Video
Updated: Jul 6, 2025
09:15
Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction
Published on: January 12, 2020
6.4K
Every tenth malignant solid tumor attributed to overweight and alcohol consumption: A population-based cohort study
Karri Seppä1, Sanna Heikkinen1, Heidi Ryynänen1
1Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
European Journal of Cancer (Oxford, England : 1990)
|January 5, 2024
Summary
Smoking and excess body weight are major cancer risk factors in Finland. Public health measures are essential to reduce cancer burden, especially for women where weight and alcohol combined are significant contributors.
Area of Science:
- Epidemiology
- Public Health
- Oncology
Background:
- Four in ten cancers are linked to key risk factors.
- Estimating population attributable fractions (PAFs) for modifiable cancer risks is crucial.
Purpose of the Study:
- To estimate cohort-based population attributable fractions (PAFs) in Finland.
- To identify and quantify the impact of modifiable cancer risk factors.
Main Methods:
- Analysis of eight health studies with 253,953 subjects and 29,802 incident malignant solid tumors.
- Bayesian multivariate regression model with multiplicative risk factor effects.
- Estimation of PAFs for smoking, body weight, alcohol, physical activity, parity, and education, accounting for competing mortality.
Main Results:
- Combined PAF for all cancers and exposures was 34% in men and 24% in women.
- Smoking accounted for 23% of cancers in men and 8% in women.
- Excess body weight and alcohol combined contributed 10% in men and 9% in women.
Conclusions:
- Smoking is the leading cancer risk factor in Finnish men and women.
- Excess body weight and alcohol consumption combined exceed smoking's impact in women.
- Increased public health focus on healthy weight is vital to decrease cancer burden.
More Related Videos
Related Concept Videos
01:24Obesity
507
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
507
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
01:19Psychoneuroimmunology: Diabetes and Cancer
29
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
29
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
01:25Statistical Methods for Analyzing Epidemiological Data
369
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
369
01:21Cancer Survival Analysis
355
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
355