Related Experiment Video
Updated: Jul 6, 2025
07:08
Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
Published on: February 2, 2024
822
The KRAS tour: Studying metabolic reprogramming in isogenic pancreatic cancer organoids
1Department of Internal Medicine, University of Chicago, Chicago, IL, USA.
Cell Stem Cell
|January 5, 2024
Abstract:
Using an isogenic organoid platform to model pancreatic cancer, Duan et al. establish an important link between mutant KRAS and cholesterol metabolism and identify perhexiline maleate as a possible therapeutic to target this relationship.
