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Related Concept Videos

Mitochondria01:37

Mitochondria

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
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Human trials exploring anti-aging medicines.

Leonard Guarente1, David A Sinclair2, Guido Kroemer3

  • 1Department of Biology, Massachusetts Institute for Technology, Cambridge, MA 02139; Academy for Healthspan and Lifespan Research (AHLR), New York, NY, USA.

Cell Metabolism
|January 5, 2024
PubMed
Summary
This summary is machine-generated.

Researchers are exploring eight drugs and natural compounds to combat age-associated diseases. Clinical trials show promise for these interventions to potentially slow or reverse aging, leading to new anti-aging medicines.

Keywords:
age-related diseaseautophagymetforminnicotinamide mononucleotide/NAD(+)/sirtuinssenescence

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Area of Science:

  • Gerontology and Translational Medicine
  • Pharmacology of Aging
  • Biomedical Research on Age-Related Diseases

Background:

  • Aging is a complex process associated with numerous chronic diseases.
  • Several drugs and natural compounds are under investigation for their anti-aging potential.
  • Clinical trials are evaluating these agents for efficacy against age-associated conditions.

Purpose of the Study:

  • To summarize current knowledge on eight promising anti-aging interventions.
  • To review their clinical testing for age-associated diseases.
  • To discuss their potential for developing new anti-aging medicines.

Main Methods:

  • Review of current scientific literature on selected drugs and natural compounds.
  • Analysis of ongoing and completed clinical trials.
  • Assessment of potential for drug repurposing for aging.

Main Results:

  • Eight agents (metformin, NAD+ precursors, GLP-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, anti-inflammatories) show promise.
  • Clinical trials are evaluating their efficacy in diseases like diabetes, cardiovascular disease, cancer, and neurodegeneration.
  • These interventions may decelerate or reverse aging processes.

Conclusions:

  • Interventions targeting aging processes may offer broad disease-preventing effects.
  • Disease-specific clinical trial outcomes can inform the development of anti-aging medicines.
  • Repurposing existing drugs may provide new avenues for treating aging consequences.