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Assessment of Usefulness of Randomized Control Trials in Child Health Research Published in 2007 and 2017

Bartosh Kaminski1, Alex Aregbesola1, Clara Tam2

  • 1Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada; Department of Pediatrics & Child Health, University of Manitoba, Winnipeg, MB, Canada.

The Journal of Pediatrics
|January 5, 2024
PubMed

Insights

Clinical usefulness in pediatric randomized controlled trials (RCTs) improved significantly over a decade. However, areas like patient centeredness and data availability require further enhancement to reduce research waste.

Area of Science:

  • Pediatric Research
  • Clinical Trials
  • Health Outcomes

Background:

  • Assessing the clinical usefulness of pediatric research is crucial for optimizing healthcare interventions.
  • Randomized controlled trials (RCTs) are a cornerstone of evidence-based medicine, but their real-world applicability can vary.
  • A decade-long analysis is needed to understand trends in the clinical utility of child health research.

Approach:

  • A comparative analysis of pediatric RCTs published in 2007 and 2017 was conducted.
  • A standardized tool evaluating 11 criteria of clinical usefulness was applied to 600 RCTs (300 per year).
  • Statistical methods were employed to assess changes in clinical usefulness over the 10-year period.

Key Points:

  • The mean clinical usefulness score for pediatric RCTs increased from 6.07 in 2007 to 9.20 in 2017.
  • Improvements were noted in reporting of context placement, funding, and conflict of interest statements.
  • Patient centeredness, value for money, and raw data availability remain underreported areas.

Conclusions:

  • Pediatric research demonstrates enhanced clinical usefulness over a 10-year span.
  • Despite improvements, significant opportunities exist to further increase the clinical utility of pediatric studies.
  • Addressing current gaps can help minimize research waste and maximize the impact of child health research.
Abstract

Keywords:
researchusefulnesswaste

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