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Updated: Jul 6, 2025

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration
Published on: June 7, 2014
Regulators of necroinflammation in acute kidney injury
Hans-Joachim Anders1, Joachim Andrassy2, Julia Lichtnekert1
1Renal Division, Department of Medicine IV, University Hospital of the Ludwig Maximilian University, Munich, Germany.
Abstract:
Interleukin (IL)-22 is unique among the ILs as it elicits direct effects on kidney epithelia and regulates cell survival in a context-dependent manner. Studies published in Kidney International and other journals demonstrate opposing roles of IL-22 (e.g., in models of acute kidney injury). In the early necroinflammation phase of acute kidney injury, IL-22 promotes tubular cell death, whereas it enhances the proliferation and regeneration of epithelial barrier function in the healing phase of injured tubules.
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