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A new alternative: inhibiting complement activation in patients with IgA nephropathy

Jürgen Floege1

  • 1Division of Nephrology and Immunology, RWTH University of Aachen, Aachen, Germany.

Kidney International
|January 5, 2024
PubMed

Mesangial complement C3 deposits, reflecting alternative and possibly lectin pathway activation, are characteristic in biopsies of patients with IgA nephropathy (IgAN). A recent randomized controlled trial tested the efficacy and safety of iptacopan, a factor B inhibitor, in patients with IgAN. Iptacopan dose-dependently reduced proteinuria, and there was a pronounced decrease of urinary C5b-9. This offers the perspective of "personalizing" therapy, which would be a unique feature of this novel approach to IgAN. A phase III clinical trial (APPLAUSE-IgAN) is ongoing.

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