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Nonlinearity association between hyperuricemia and all-cause mortality in patients with chronic kidney disease

Ya-Fei Liu1, Liang Han2, Yin-Hong Geng3

  • 1Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, Henan, China. yafeiliutjh@gmail.com.

Scientific Reports
|January 5, 2024
PubMed

Insights

High serum uric acid levels are linked to increased mortality risk in patients with chronic kidney disease (CKD). This study highlights the importance of monitoring uric acid in CKD patients for better outcomes.

Area of Science:

  • Nephrology
  • Cardiovascular Research
  • Metabolic Disease

Background:

  • The prognostic value of serum uric acid (SUA) in chronic kidney disease (CKD) progression and mortality remains debated.
  • Large-scale cohort studies are needed to clarify the association between SUA levels and mortality risk in CKD patients.

Purpose of the Study:

  • To investigate the association between serum uric acid concentrations and mortality risk in a large cohort of patients with chronic kidney disease (CKD).

Main Methods:

  • Utilized data from National Health and Nutrition Examination Survey participants with CKD (1998-2017).
  • Employed multivariable Cox regression models to analyze SUA levels and CKD mortality.
  • Applied restricted cubic spline curves to assess nonlinearity in the association.

Main Results:

  • A total of 9891 CKD patients were included, with 3698 deaths during follow-up.
  • Elevated SUA levels were independently associated with increased mortality risk in CKD patients (HR per SD increase).
  • A nonlinear association was observed between SUA and mortality (p=0.046), with levels ≥ 5.900 mg/dL showing a significant increase in risk (HR=1.102).

Conclusions:

  • High serum uric acid levels (≥ 5.900 mg/dL) are associated with significantly increased mortality risks in patients with chronic kidney disease (CKD).
  • Findings suggest potential therapeutic implications for managing SUA in CKD management strategies.

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