Related Experiment Video
Updated: Jul 6, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Aminocarbonylation Reaction Using a Pd-Sn Heterobimetallic Catalyst: Three-Component Coupling for Direct Access of
Anuradha Mohanty1, Soheli Sadhukhan1, Mukesh Kumar Nayak1
1Organometallics & Catalysis Laboratory, School of Basic Sciences Indian Institute of Technology Bhubaneswar Arugul, Khurda, Jatani, Odisha 752050, India.
Abstract:
A heterobimetallic "Pd-Sn" catalyst, namely, PdCl(PPh3)2SnCl3, efficiently catalyzes the aminocarbonylation reaction of aryl iodides with amines under the atmospheric pressure of CO in the absence of a base and additive. Primary, secondary, and alkyl amines all afforded the corresponding amides in good to excellent yields with high selectivity. A broad range of functional groups were tolerated. The method was further extended to the synthesis of biologically active isoindoline-1,3-diones in the presence of triethylamine. A mechanism is proposed for the reaction.
More Related Videos
11:44Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
19:58Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Related Concept Videos
Alkenes via Reductive Coupling of Aldehydes or Ketones: McMurry Reaction
Preparation of Amides
The DCC-promoted synthesis of amides begins with the protonation of DCC by carboxylic acid. The protonation makes it a better acceptor. Next, the addition of carboxylate to the protonated carbodiimide gives a reactive acylating agent.
Subsequently, the amine acts as a nucleophile that attacks the acylating agent to form a tetrahedral intermediate. In the...
Amines to Amides: Acylation of Amines
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary...
Vicinal Diols via Reductive Coupling of Aldehydes or Ketones: Pinacol Coupling Overview
Nucleophilic Aromatic Substitution: Elimination–Addition
α-Bromination of Carboxylic Acids: Hell–Volhard–Zelinski Reaction