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Updated: Jul 6, 2025

Assays for Validating Histone Acetyltransferase Inhibitors
Published on: August 6, 2020
Integrative function of histone deacetylase 3 in inflammation
Junjie Li1, Yiyuan Zhai1, Min Tang2
1Institute of Biochemistry and Molecular Biology, Hengyang College of Medicine, University of South China, Changsheng West Road 28, Hengyang, 421001, China.
Abstract:
Inflammation is a complex biological response triggered when an organism encounters internal or external stimuli. These triggers activate various signaling pathways, leading to the release of numerous inflammatory mediators aimed at the affected tissue. Ensuring precision and avoiding the excessive activation, the inflammatory process is subject to tight regulation. Histone deacetylase 3 (HDAC3), a member of class I HDACs family, stands out for its significant role in modulating various inflammatory signaling, including Nuclear Factor kappa B (NF-κB) signaling, Mitogen-activated protein kinase (MAPK) signaling and Janus kinase/signal transduction and activator of transcription (JAK-STAT) signaling. In this review, we illuminate the intricate molecular mechanisms of HDAC3 across these inflammatory pathways. We emphasize its importance in orchestrating a balanced inflammatory response and highlight its promising potential as a therapeutic target.
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