Related Experiment Video

Updated: Jul 6, 2025

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.4K

Atmospheric environment and persistence of pediatric asthma: A population-based cohort study

Hwan Soo Kim1, Kyunghoon Kim2, Eun Hee Rhee3,4

  • 1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Asian Pacific Journal of Allergy and Immunology
|January 6, 2024
PubMed

Insights

Childhood asthma often resolves, but some children experience persistent symptoms into adulthood. Factors like younger age at enrollment, male sex, air pollution exposure, and food allergies increase the risk of asthma persistence.

Area of Science:

  • Pediatric Allergy and Immunology
  • Environmental Health
  • Epidemiology

Background:

  • Asthma in children is heterogeneous, with a significant portion experiencing symptom resolution by adulthood.
  • However, data linking childhood asthma trajectories to adult outcomes remain limited.

Purpose of the Study:

  • To identify factors associated with the persistence of childhood asthma over a three-year follow-up period.
  • To link data from the Korea Childhood Asthma Study (KAS) with national health insurance claims (HIRA) for comprehensive analysis.

Main Methods:

  • Analysis of 450 preadolescent children (aged 7-10) categorized into asthma remission or persistence groups.
  • Comparison of baseline clinical characteristics and exposure to air pollutants (PM2.5, PM10).
  • Asthma persistence defined by healthcare utilization and medication prescriptions within three years post-enrollment.

Main Results:

  • Lower enrollment age, male sex, proximity to air-polluting facilities, higher PM2.5 levels, and diagnosed food allergy were significant risk factors for asthma persistence.
  • Specific adjusted odds ratios (aOR) and confidence intervals (CI) were reported for each factor.

Conclusions:

  • Several independent risk factors for persistent childhood asthma were identified.
  • Linking KAS and HIRA data enabled clarification of these risk factors in a defined population.
Abstract

More Related Videos

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India09:33

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India

Published on: December 23, 2022

2.2K
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

31.9K

Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
405
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
2.5K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K