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Base Excision Repair

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...

Long-patch Base Excision Repair

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:

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Related Experiment Video

Updated: Jul 6, 2025

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence

Published on: March 9, 2015

Reverse engineering in forensic investigations: a new approach to bite mark analysis.

E Macorano¹, F Mele¹, M Calvano¹

¹Section of Legal Medicine, Interdisciplinary Department of Medicine, Bari University, Italy.

The Journal of Forensic Odonto-Stomatology

|January 6, 2024

Summary

This summary is machine-generated.

Forensic bite mark analysis can identify individuals using 3D imaging. This pilot study successfully used reverse engineering to compare a bite mark on a bun to dental models, confirming victim dental compatibility.

Area of Science:

Forensic Science
Digital Imaging
Odontology

Background:

Bite mark analysis is vital in identifying individuals in forensic investigations.

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Bite marks can be found on victims or at crime scenes, such as on food items.

Comparing bite marks to suspect dentition is crucial for culpability assessment.