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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Chapter 1: The Burden of Heart Failure
Richard Pratley1, Xuan Guan2, Richard J Moro3
1AdventHealth Translational Research Institute, Orlando, Fla.
Insights
Heart failure (HF) is a growing concern, affecting millions and increasing healthcare costs. Early diagnosis and new treatments offer hope for better survival and quality of life for patients with this condition.
Area of Science:
- Cardiology
- Public Health
Background:
- Heart failure (HF) affects 6 million American adults, with increasing prevalence due to aging and diabetes.
- Improved survival leads to more individuals living longer with HF, impacting quality of life and increasing morbidity and mortality.
- HF management incurs significant healthcare costs, primarily from hospitalizations.
Purpose of the Study:
- To highlight the growing burden of heart failure.
- To emphasize the role of clinicians in HF management.
- To underscore the importance of prevention and early diagnosis.
Main Methods:
- This abstract reviews current trends and challenges in heart failure management.
- It discusses the impact of comorbidities and advances in pharmacotherapy.
Main Results:
- Heart failure prevalence is rising, driven by demographic and comorbidity factors.
- Effective treatments and early diagnosis are crucial for reducing HF burden.
- Pharmacotherapies show potential for improving HF patient outcomes.
Conclusions:
- Timely diagnosis and access to effective treatments are essential for managing heart failure.
- Prevention and early detection are key to mitigating the increasing impact of HF.
- Advances in pharmacotherapy may significantly improve survival and quality of life for HF patients.
Abstract:
Heart failure (HF) affects an estimated 6 million American adults, and the prevalence continues to increase, driven in part by the aging of the population and by increases in the prevalence of diabetes. In recent decades, improvements in the survival of patients with HF have resulted in a growing number of individuals living longer with HF. HF and its comorbidities are associated with substantial impairments in physical functioning, emotional well-being, and quality of life, and also with markedly increased rates of morbidity and mortality. As a result, the management of patients with HF has a substantial economic impact on the health care system, with most costs arising from hospitalization. Clinicians have an important role in helping to reduce the burden of HF through timely diagnosis of HF as well as increasing access to effective treatments to minimize symptoms, delay progression, and reduce hospital admissions. Prevention and early diagnosis of HF will play a fundamental role in efforts to reduce the large and growing burden of HF. Recent advances in pharmacotherapies for HF have the potential to radically change the management of HF, offering the possibility of improved survival and quality of life for patients.
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