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Altering phosphorylation in cancer through PP2A modifiers

Hannah Johnson1, Satya Narayan2, Arun K Sharma3

  • 1Department of Pharmacology, Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.

Cancer Cell International
|January 6, 2024
PubMed

Insights

Protein phosphatase 2A (PP2A) is crucial for cellular processes. Deregulation of PP2A in cancer promotes tumor growth, making PP2A inhibitors and activators promising therapeutic strategies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Protein phosphatase 2A (PP2A) is a key serine/threonine phosphatase regulating numerous cellular functions.
  • PP2A dysregulation is implicated in cancer progression, driving tumor growth.
  • Targeting PP2A offers a therapeutic avenue for cancer treatment.

Purpose of the Study:

  • To review the role of PP2A in cancer.
  • To discuss PP2A's downstream signaling pathways in cancer regulation.
  • To explore PP2A activators and inhibitors as anti-cancer agents.

Main Methods:

  • Literature review of PP2A deregulation in cancer.
  • Analysis of PP2A's role in cancer signaling pathways.
  • Compilation of known PP2A modulators (activators and inhibitors).

Main Results:

  • PP2A deregulation contributes to tumor progression.
  • PP2A modulators demonstrate efficacy in various cancers, including drug-resistant types.
  • PP2A targeting can synergize with existing cancer therapies.

Conclusions:

  • PP2A is a significant target for cancer therapy.
  • Modulating PP2A activity through inhibitors or activators can impede cancer progression.
  • PP2A-targeted therapies hold promise for overcoming drug resistance and enhancing treatment efficacy.
Keywords:
ActivatorsCancerInhibitorsPP2ATherapeutics

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