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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
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Early left ventricular microvascular dysfunction in diabetic pigs: a longitudinal quantitative myocardial perfusion
Li Jiang1, Wei-Feng Yan1, Lu Zhang2
1Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan, 610041, China.
Cardiovascular Diabetology
|January 6, 2024
Summary
Diabetic cardiomyopathy involves microvascular issues. This study shows early diabetes mellitus in pigs leads to decreased myocardial microvascular reserve function, linked to structural and functional microvessel changes, not reduced density.
Area of Science:
- Cardiology
- Diabetology
- Medical Imaging
Background:
- Diabetic cardiomyopathy is characterized by microvascular pathology.
- The early longitudinal progression of diabetic microvascular dysfunction is not well understood.
Purpose of the Study:
- To investigate the early dynamic changes in left ventricular (LV) microvascular function in a diabetic pig model.
- Utilize cardiac magnetic resonance (CMR)-derived quantitative perfusion techniques to assess these changes over time.
Main Methods:
- Twelve pigs underwent streptozotocin-induced diabetes mellitus (DM) and serial CMR scans over 16 months.
- Analyzed semiquantitative and quantitative perfusion parameters (e.g., myocardial blood flow [MBF], myocardial perfusion reserve [MPR]) to evaluate LV microvascular function.
- Correlated LV structure and function with myocardial perfusion using Pearson correlation.
Main Results:
- Myocardial perfusion reserve function (MPRI, MPR) decreased significantly with DM duration (P<0.05).
- LV MPR correlated with LV longitudinal strain, remodeling index, fasting blood glucose, and HbA1c.
- Histopathology revealed increased collagen but no significant reduction in microvascular density.
Conclusions:
- Early-stage diabetes mellitus leads to a gradual decrease in myocardial microvascular reserve function.
- This decline is associated with microvascular structural and functional abnormalities, increased blood glucose, reduced LV deformation, and myocardial remodeling.
- Microvascular density was not significantly reduced in the early stages of diabetic cardiomyopathy.
