Nutritional supplements and IVF: an evidence-based approach.

Area of Science:

• Reproductive Medicine
• Nutritional Science
• In Vitro Fertilization (IVF)

Background:

• Many women utilize nutritional supplements during IVF treatment.
• Evidence for the efficacy of various supplements is often inconclusive.
• Optimizing nutrition is crucial for successful fertility outcomes.

Purpose of the Study:

• To systematically review nutritional supplements used by women undergoing IVF.
• To evaluate the evidence for specific supplements including dehydroepiandrosterone (DHEA), melatonin, co-enzyme Q10 (CoQ10), and others.
• To provide insights into potential benefits and areas needing further research.

Main Methods:

• Comprehensive literature search conducted up to May 2023.
• Systematic review of studies investigating various nutritional supplements and dietary interventions.
• Analysis of data related to IVF outcomes and specific patient populations.

Main Results:

• A Mediterranean diet is suggested as a beneficial nutritional approach.
• Dehydroepiandrosterone (DHEA) and co-enzyme Q10 (CoQ10) show promise for improving ovarian response when started pre-cycle.
• Melatonin, myo-inositol, vitamin D, and omega-3 fatty acids may offer benefits, but optimal use and patient groups require further clarification.

Conclusions:

• Nutritional interventions, including specific supplements and dietary patterns, may positively impact IVF success.
• Further research is needed to determine optimal dosing and patient selection for supplements like melatonin, myo-inositol, and vitamin D.
• CoQ10 and DHEA show potential for enhancing ovarian response in IVF cycles.