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Related Concept Videos

Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

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The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
268

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Mortality and Autopsy Findings in Patients with Pyoderma Gangrenosum: A Multi-Institutional Series.

Hadir Shakshouk1, Mallory deCampos-Stairiker2, Shannon Kody1

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Pyoderma gangrenosum (PG) increases mortality risk, often due to infection and other complications. Systemic steroids may exacerbate these fatal risks in patients with underlying conditions.

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Area of Science:

  • Dermatology
  • Pathology
  • Internal Medicine

Background:

  • Pyoderma gangrenosum (PG) is a rare ulcerative condition associated with increased mortality.
  • Causes of increased mortality in PG are poorly understood, and misdiagnosis is common.
  • This study reviewed autopsy findings to determine causes of death in confirmed PG cases.

Discussion:

  • Infection was the leading cause of death (54.5%) in the studied PG patients.
  • Pulmonary embolism (27.3%) and myelodysplastic syndrome (18.2%) were other significant causes of mortality.
  • Over half of patients (54.5%) were on systemic steroids at the time of death, potentially increasing complication risks.

Key Insights:

  • PG may reduce life expectancy, particularly in patients with associated inflammatory or hematologic conditions.
  • Infection, thrombosis, and malignancy are critical risks to manage in PG patients.
  • Autopsy findings confirm infection as the primary cause of death in this cohort.

Outlook:

  • Further research is needed to elucidate the link between PG and thromboembolism.
  • Increased awareness of PG-associated risks is crucial for effective patient management.
  • Investigating the impact of PG treatments on mortality risks requires further study.