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Related Experiment Video

Updated: Jul 6, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Migraine as an allostatic reset triggered by unresolved interoceptive prediction errors.

William Sedley1, Sukhbinder Kumar2, Siobhan Jones1

  • 1Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.

Neuroscience and Biobehavioral Reviews
|January 7, 2024
PubMed
Summary

Migraine may be an adaptive failsafe mechanism for allostasis, a bodily regulation process. However, it can become maladaptive if excessively triggered, leading to intense sensory experiences.

Keywords:
Active inferenceAllostasisHomeostasisInteroceptionMigraine

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Area of Science:

  • Neuroscience
  • Computational Psychiatry
  • Physiology

Background:

  • Migraine's cause and purpose remain unclear.
  • Allostasis and active inference offer potential explanatory frameworks.

Purpose of the Study:

  • To explain migraine within the theoretical frameworks of allostasis and active inference.
  • To elucidate the role of prediction error in migraine pathophysiology.

Main Methods:

  • Conceptual analysis integrating allostasis and active inference theories.
  • Explanation of migraine phases (premonitory, attack) through prediction error amplification.

Main Results:

  • Migraine is proposed as a 'failsafe' mechanism for allostasis, triggered by persistent, amplified prediction errors.
  • Elevated prediction error, particularly concerning interoception, signals potential allostatic dysfunction.
  • The premonitory phase involves broad amplification of errors to prioritize resolution.

Conclusions:

  • Migraine serves as a critical, albeit potentially maladaptive, regulatory process for maintaining physiological stability.
  • Understanding migraine through allostasis and active inference may reveal new therapeutic targets.