Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Imipramine and tinnitus.

R Tandon, L Grunhaus, J F Greden

    The Journal of Clinical Psychiatry
    |March 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Tricyclic antidepressants can cause tinnitus, a rare neurologic side effect, in about 1% of patients. This tinnitus often resolves spontaneously within weeks, even with continued treatment.

    Related Experiment Videos

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Transcranial magnetic stimulation is effective in the treatment of relapse of depression.

    International journal of psychiatry in clinical practice·2014
    Same author

    Sleep Electroencephalographic Studies After ECT.

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2011
    Same author

    Cognitive behavioral group therapy in panic disorder patients: the efficacy of CBGT versus drug treatment.

    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists·2004
    Same author

    Response to ECT in major depression: are there differences between unipolar and bipolar depression?

    Bipolar disorders·2002
    Same author

    Transcranial magnetic stimulation in patients with bipolar depression: a double blind, controlled study.

    Bipolar disorders·2002
    Same author

    The efficacy of reboxetine in the treatment-refractory patients with panic disorder: an open label study.

    Human psychopharmacology·2002
    Same journal

    Major Depressive Disorder and PTSD Treatment Outcome in Interpersonal Psychotherapy and Prolonged Exposure.

    The Journal of clinical psychiatry·2026
    Same journal

    Psychiatrists and Medical Aid in Dying: Entering Uncharted Waters.

    The Journal of clinical psychiatry·2026
    Same journal

    Mind and Metabolism in Crisis: US Mortality Involving Obesity and Psychiatric Disorders-Trends, Disparities, and ARIMA Projections.

    The Journal of clinical psychiatry·2026
    Same journal

    Generative AI for the Clinical Psychopharmacologist: Is It Ready for Prime Time?

    The Journal of clinical psychiatry·2026
    Same journal

    Posttrauma Benzodiazepine Use and Subsequent PTSD: A Population-Wide Analysis Following Extreme Traumatic Exposure.

    The Journal of clinical psychiatry·2026
    Same journal

    The Challenges of PTSD Prevention: Placing Benzodiazepine Use in Context.

    The Journal of clinical psychiatry·2026
    See all related articles

    Area of Science:

    • Neuropharmacology
    • Clinical Psychiatry

    Background:

    • Tinnitus is a rare neurologic side effect of tricyclic antidepressants (TCAs).
    • Limited data exists on the prevalence, mechanism, course, and management of TCA-induced tinnitus.

    Observation:

    • A chart review of 475 patients on TCAs found tinnitus in approximately 1% of cases.
    • Five case vignettes detail tinnitus onset during imipramine therapy (150-250 mg/day).

    Findings:

    • Tinnitus developed within 2-3 weeks of imipramine initiation.
    • Plasma imipramine-desipramine levels ranged from 200-450 ng/ml.
    • Tinnitus resolved spontaneously in 2-4 weeks despite stable or increased TCA dosage and plasma levels.

    Implications:

    • TCA-induced tinnitus may be transient and self-limiting.
  • Monitoring and potential dose adjustments may be considered for patients experiencing tinnitus.
  • Further research is needed to elucidate the precise mechanisms underlying TCA-associated tinnitus.