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Myeloid-derived growth factor and its effects on cardiovascular and metabolic diseases

Jinling Xu1, Yanzhuo Song2, Sheng Ding1

  • 1Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.

Cytokine & Growth Factor Reviews
|January 7, 2024
PubMed

Insights

Myeloid-derived growth factor (MYDGF) offers protective benefits for cardiovascular health, aiding in heart repair and preventing heart failure. It also shows promise in treating metabolic diseases like diabetes and liver conditions.

Area of Science:

  • Cardiovascular Biology
  • Metabolic Disease Research
  • Regenerative Medicine

Background:

  • Myeloid-derived growth factor (MYDGF) is a paracrine protein secreted by monocytes and macrophages.
  • Existing research indicates MYDGF possesses cardioprotective properties.
  • MYDGF also demonstrates potential therapeutic effects in metabolic disorders.

Purpose of the Study:

  • To review the biological functions of MYDGF.
  • To explore the role of MYDGF in cardiovascular diseases.
  • To discuss the impact of MYDGF on metabolic diseases.

Main Methods:

  • Literature review of studies on MYDGF.
  • Analysis of experimental data on MYDGF's effects.
  • Synthesis of findings related to cardiovascular and metabolic applications.

Main Results:

  • MYDGF promotes heart tissue repair post-myocardial infarction and enhances cardiomyocyte proliferation.
  • It improves cardiac regeneration, regulates endothelial cell function, and protects against heart failure and atherosclerosis.
  • MYDGF shows efficacy in improving type 2 diabetes, non-alcoholic fatty liver disease, glomerular diseases, and osteoporosis.

Conclusions:

  • MYDGF is a significant factor in cardiovascular protection and regeneration.
  • MYDGF holds therapeutic potential for a range of metabolic diseases.
  • Further research into MYDGF biology and applications is warranted.

Keywords:
Cardiovascular diseasesMetabolic diseasesMyeloid-derived growth factor

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