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Exploring the relationship between hyperlactatemia and anemia.

Shuping Zhang¹, Wei Liu², Tomas Ganz³

¹Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China.

Trends in Endocrinology and Metabolism: TEM

|January 7, 2024

Summary

This summary is machine-generated.

Anemia and hyperlactatemia (high blood lactate) often occur together. New research suggests lactate is a key signaling molecule influencing anemia, requiring further study into its complex roles.

Keywords:

anemia hepcidin hyperlactatemia iron deficiency lactate lactic acidosis

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Area of Science:

Biochemistry
Physiology
Pathology

Background:

Hyperlactatemia and anemia frequently coexist, with unclear underlying mechanisms.
Lactate is increasingly recognized as a signaling molecule, not just a metabolic byproduct.
Hyperlactatemia can induce iron restriction by increasing hepcidin expression.

Purpose of the Study:

To explore the intricate relationship and mutual influence between anemia and hyperlactatemia.
To highlight the significance of lactate and lactylation in the context of anemia.
To identify critical knowledge gaps concerning lactate's role in anemia.

Main Methods:

Literature review and synthesis of current evidence.
Discussion of existing research on lactate metabolism and signaling.
Identification of areas requiring further investigation.

Main Results:

Lactate influences anemia, notably by upregulating hepcidin, which restricts iron availability.
The crosstalk between hyperlactatemia and anemia involves complex signaling pathways.
Lactate's role extends beyond metabolism to active molecular signaling.

Conclusions:

A deeper understanding of lactate's multifaceted roles in anemia is necessary.
Further research should focus on lactate's dose-dependency, sources, and subcellular actions.
Reconsidering lactate and lactylation is crucial for understanding anemia pathophysiology.